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Participants with renal impairment were recruited before those with normal renal function to help ensure similarity across groups in age and body weight

Softer substrates promote chondrogenesis in MSCs and NP progenitor cells, upregulating aggrecan, Sox9, and collagen II expression (Olivares-Navarrete et al., 2017

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Together, the JAK/STAT/hepcidin and JAK/STAT/IRF1 pathways promote the loss of neurons and microglia, thereby contributing to brain damage and depressive-like behaviors