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3.3.1.2 Targeting inflammatory mediators/pathways More targeted approaches focus on specific cytokines or signaling pathways activated by oxidative stress and inflammation

A Mendelian randomization analysis based on large genome-wide association study (GWAS) demonstrated that genetic liability to schizophrenia is associated with an increased risk of all-cause dementia, AD, and VaD (96)

High homocysteine level is a known risk factor for increasing the risk of heart disease, blood clots, and pregnancy complications in pregnant women ( 9 )

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However, under starvation cells increase production of mitochondrial-derived hydrogen peroxide, which has been shown to be partly dependent on the activation of class III PI3K (Scherz-Shouval and Elazar, 2007)

Notably, reactive astrocytes aberrantly produce GABA from putrescine via MAO-B, releasing it through the BEST1 channel 58,59