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The modulation of ferroptotic cell death presents a promising treatment strategy for psoriasis, as evidenced by the efficacy of specific inhibitors such as ferrostatin-1 and liproxstatin-1 in shielding keratinocytes from inflammatory damage in experimental studies (194)

10.1016/s0304-419x(01)00027-0 59 DarveshS.HopkinsD

10.1038/s41598-023-29941-x 117 MahfudhN.SulistyaniN.AdhilaG

The solutions were placed in 15 mL sterile polypropylene centrifuge tubes with screw caps (VWR), which were denatured by suspending them in a water bath at 95 C for 15 min

They may recommend the initiation of sodium phenylacetate/sodium benzoate (ammonia scavengers) and L-arginine in an attempt to provide alternative methods for nitrogen excretion and override the OTC defect at the initial step of the urea cycle or to treat undifferentiated inborn errors of metabolism ( Figure 4 )