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Still, research shows that some groups are more likely to be affected

Similarly, promoter methylation of miR-143 [144] and miR-200b/c [145] reduces their expression, causing them to lose their ability to target and inhibit DNMTs, which indirectly exacerbates abnormal DNA methylation accumulation and reinforces the drug resistance cycle

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Consequently, buyers should request product literature, manufacturer inserts, and applicable safety documents before supply