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Description

An unexpected observation was made when we analysed the cell cycle impact of trichloroacetonitrile

L.HayleyS.MountM

The addition of the acetyl group makes the molecule more lipophilic (fat-soluble), allowing it to interact uniquely with specialized transport proteins in the body, fundamentally changing where it can go and what it can do once it gets there

It can enhance the anti-tumor effects of drugs like first-line molecular drugs (adriamycin, cisplatin, and paclitaxel) and targeted drugs (sorafenib) in breast cancer (MCF-7 and MDA-MB-231), ovarian cancer (SK-OV-3 and A2780), osteosarcoma (HOS and 143B), lung cancer (A549), and liver cancer (Hep G2) cells [1045]

Jonsjo MA, Olsson GL, Wicksell RK, Alving K, Holmstrom L, Andreasson A

Adoptive cell therapy (ACT) using activated CD8 + T cells with genetic deletion of GPX4 also failed to enable antitumor immunity and subsequent tumor control