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This intramolecular salt bridge is present on the same face of the peptide -helix in the active state AMYR structures and rotamers of both residues constrain each other with their sidechains located close to ECL2 of the CTR protomer (Fig

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Staley K, Ahmadi KR, Carter K, et al

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We are trying to obtain a biopsy and have a better description of this reaction, she says

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