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Thus, it became an effective target for covalent BTK inhibitors such as ibrutinib ( The most frequent cytogenetic mutation in CLL is the 13q deletion (del[13q]), found in around 50% of CLL cases ( One of the biggest challenges in treating CLL is the development of resistance to BTK and BCL-2 inhibitors

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Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: Implications for folate intake recommendations

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ATAC-seq digital genomic footprinting Footprinting analysis to determine TF occupancy was performed on sample-merged bam files (samtools merge 93 ) and sample-merged narrowpeak output from MACS2 using the Wellington algorithm from the pyDNase package v0.3.0 112