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Experts dont know exactly why it happens, but metformin can block the absorption of vitamin B12 in the intestine, according to an article published in 2022

These past studies indicated that not only chemical but also mechanical cues could drive the progression of many pathophysiological states (Velasco-Estevez et al., 2022)

(2016, PMID: 26378576) found that higher magnesium intake was associated with significantly reduced risk of vitamin D deficiency

10.1016/j.ejphar.2012.11.055 [DOI] [PubMed] [Google Scholar] 23

Analysis of the conservation of lysine 447 in USP2 A gene panel of the NCBI database ( was used to download amino acid sequences of proteins from multiple species and subsequently compare sequence conservation between species using the UGENE software (version 39