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Zhang C, Zhang Y, Dong Y, Zi R, Wang Y, Chen Y

10.1038/d41586-019-03122-1 60 JaschkeN

Given that the degradation of KEAP1 encompasses two distinct pathways, namely autophagy 29 and proteasomal degradation 30 , we employed the protein synthesis inhibitor cycloheximide (CHX), the proteasome inhibitor MG132, and the autophagy inhibitor chloroquine (Chlq) to further explore the underlying mechanism in macrophages (Fig

Cell culture Raw 264.7 cells (murine mononuclear macrophage cell line) were kindly provided by Cell Bank/Stem Cell Bank, Chinese Academy of Sciences

It inhibits the absorption of cholesterol

The QCN-HS also exhibited histological evidence of dermal repair, including reduced inflammatory infiltration, organized collagen deposition, and enhanced vascular density, supporting the observed molecular changes