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doi: 10.1021/ja012221q

Its not uncommon in medicine to encounter situations where a treatment, especially one addressing a longstanding deficiency, might initially seem to exacerbate symptoms

LR3 IGF-1 is a modified analog of human IGF-1 with a 13-amino acid extension at the N-terminus and a substitution of Arg at position 3, which significantly reduces its affinity for IGF-binding proteins

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Several studies reported that aerobic metabolism is the preferential mechanism through which cancer cells produce their energy (converting glucose into lactate followed by ATP production) to maintain their sustained and rapid proliferation in the hypoxic TME