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Xiaoyao San ameliorates high-fat diet-induced anxiety and depression via regulating gut microbiota in mice

Parkinsons disease: content analysis of patient online discussion forums

Collectively, tissue breakdown products (including DAMPs), macrophage-derived stress mediators, gut-derived endotoxemia, and ongoing metabolic injury can facilitate a shift from predominantly local to more systemic meta-inflammatory involvement, recruiting additional organs and vascular compartments

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They act as the body's signaling molecules

The choice depends on your priorities: convenience (with DAC) versus physiological release patterns (without DAC)