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In HFD-fed mice, the treatment demonstrated improvements in glucose tolerance, reduced hepatic steatosis, and alleviated adipose inflammation, partially by restoring oxidative stress, inflammation, and ERSrelated gene expression through SIRT1 (Yoshino et al

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Initial supplemental dose is usually 1000-2000 g/day for week or two and then 1000 g/day for life

In addition, antioxidants have also been shown to be capable of reversing certain altered biochemical variables and this ability enhances its potential to provide for optimal therapeutic benefits while causing fewer or minimal side effects

Nonetheless, the bioavailability and blood concentration remained low despite relatively high doses and short intervals between them