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For example, inhibition of phosphofructokinase-1 leads to the accumulation of fructose 6-phosphate, which, via the phosphoglucose isomerase reaction, increases glucose 6-phosphate levels

Adams, C

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The available data, however, are limited and inadequate to reliably quantify sex-related differences in toxicity

D.2001Casarett and Doull`s Toxicology: The Basic Science of Poisons