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These changes were likely a result of FPN-induced oxidative stress, generation of ROS, mitochondrial dysfunction, and cytoskeleton disruption, which consequently led to cell death 62,63

Table 2 Number of animals positive for MAP culture

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GHK-Cu delivers the copper required by SOD directly to the cell while simultaneously promoting the expression of the SOD gene

The monolayers were initially washed with HBSS, then equilibrated for 30 min by adding 1.6 mL DMEM D1145 to the apical side and 4 mL to the basolateral side

634413) and the Innovative Medicines Initiative 2 Joint Undertaking under the LITMUS project (grant no