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The RDA The recommended dietary allowance (RDA) for thiamin, revised in 1998 by the Food and Nutrition Board of the Institute of Medicine, was based on the prevention of deficiency in generally healthy individuals (37

The cases of brain disorders by 2050 are projected to have a 22% increase from 2021 estimates, with the most prevalent conditions being migraine, Alzheimers disease, depressive and anxiety disorders, and strokes (Lei and Gillespie, 2024)

Therefore, Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were carried out on the DEGs to explore the potential functions of the top 10 mostly changed terms (Fig