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Abstract Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the worlds poorest children and women of childbearing ages across regions of sub-Saharan Africa

Adulteration with synthetic drugs (e.g., corticosteroids in anti-diarrheal preparations) or contamination with heavy metals and pesticides further undermines safety

To address this, we additionally deleted the gene coding for Ggt in these cells and analyzed reduction of Grx1-roGFP2 by exogenous GSH in the resulting gshA gsiC ggt triple deletion mutant

Helps to increase intracellular stores of Glutathione 5

[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Pirozzi F.F., Belini Junior E., Okumura J.V., Salvarani M., Bonini-Domingos C.R., Ruiz M.A

Grossmann A, Wendel A