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A decline in ACE2 function in aged individuals, coupled with the age-associated deterioration in mitochondrial functions results in chronic metabolic disorders like diabetes or cancer, and predisposes the host for increased susceptibility to infection, vulnerability to health complications, and intensifies the risk of mortality 163

doi: 10.1038/s42003-023-05477-8 115 EberhardYMcDermottSPWangXGrondaMVenugopalAWoodTEet al

Flavonol aglycones are rapidly metabolized via glucuronidation and sulfation but retain partial bioactivity

(2013) generated some of the few xenografts of pediatric low-grade astrocytomas available at that time