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Neurology 86 , 10701071 (2016)

Selenocysteine is one such example (sometimes even thought of as the 21st amino acid) and is unique for multiple reasons, specifically that its the only amino acid that contains an essential nutrient, selenium

Yes, in many cases

doi: 10.1007/s12035-021-02297-x 290

handfoot syndrome), constipation, nausea, vomiting, hypercalcemia, increased creatinine, increased AST, anemia, arthralgia, and abdominal or back pain (Abou-Alfa et al., 2020