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A 2015 Cell Metabolism study that first characterized MOTS-c as a mitochondria-derived regulator of metabolic homeostasis capable of reducing obesity and insulin resistance in animal models was foundational in establishing this peptide class

doi: 10.1016/j.tvjl.2009.09.013 10 Brigelius-FlohR.FlohL

Leisure-time and occupational physical activity and health outcomes in cardiovascular disease

doi: 10.1016/j.neuroscience.2021.06.033 194 ZhongM.ZhuS.GuR.WangY.JiangY.BaiY.et al

developed a PLGA-based nanocarrier for PD therapy, combining pramipexole (PX, a dopamine agonist) with a photothermal agent (Au nanospheres) encapsulated in PLGA nanoparticles (Au-PX-PLGA) 125