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This increase in SIRT1 facilitated the cytosolic accumulation of -catenin and promoted its translocation into the nucleus [128, 129]

ROS induce oxidative DNA damage in sperm through single- and double-strand breaks and base modifications, such as 8-hydroxy-2-deoxyguanosine (8-OHdG), as demonstrated by Jeng et al [92]

2022;10: e13717

Finally, local refinement was performed by using a mask that enclosed the p*MHC and R302 variable chains (made using UCSF Chimera 1.18 software 80 ), resulting in the final map