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A B12 deficiency can also lead to health problems that can lead to major birth defects

Given the reduced lipid peroxidation, improved antioxidant status, and reduced DNA damage in curcumin pretreated groups, the authors concluded that curcumin may induce the transcriptional factors for oxidative stress-related gene expression [23]

Plos One, 10 , e0122741

Researchers found that metformin could regulate endometrial tolerance by increasing endometrial glucose transporter protein 4 (GLUT4) expression, modulating the expression of related hormone receptors to affect endometrial transformation, modifying autophagy, as well as modulating DNA/histone modifications and micro RNAs (miRNAs) for transcriptional regulation

Regul Toxicol Pharmacol 156:105765

In elderly individuals, a six-week structured aerobic regimen was associated with significant reductions in Beck Depression Inventory (BDI) scores, particularly in somatic symptoms, suggesting that physical activity contributes to emotional well-being and mood stabilization [67]