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As per the latest diagnostic criteria, MetS necessitates the presence of any three out of the following five conditions: elevated fasting glucose or type 2 diabetes (T2D), hypertriglyceridemia, lowered high-density lipoprotein (HDL) cholesterol levels, central obesity, or hypertension (Tilg et al., 2020)

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during the antibodys first half-life period 68 and prior to the onset of the CD8 T cell response 69

For the foundational coverage of each compound individually, see What Is AOD-9604