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Our transcriptomic analyses highlighted certain signaling pathways common to exposure to CS and ECA (although the number of genes involved is much lower with ECA), including response to oxidative and chemical stress

This supports the view that a certain proportion of the cortical thickness/smoking association is not due to direct or indirect effects of cigarette smoking on the cortex given that those with a lower IQ have both a thinner cortex 16, 36 and a higher propensity to smoke