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cellular uptake is then mediated by ZIP (Zrt/Irt-like Protein) importers and ZnT exporters whose coordinated activity maintains nanomolar cytosolic concentrations while permitting millimolar sequestration in secretory vesicles-regulation that is crucial during stresses such as burns or sepsis when requirements rise markedly

Through a cysteine-reactive ligand screen, Boike et al

Emerging evidence suggests that dysregulated lipid metabolism, especially in key effector cells, such as T cells, B cells, and innate immune cells, exerts complex effects on the pathogenesis and progression of SLE