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This was accompanied by downregulation of renal hypoxia-inducible factor-2 and decreased expression of the bone marrow erythropoietin receptor and TFR (212)

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Experimental studies demonstrate that capsaicin significantly reduces FAS and ACC expression at both mRNA and protein levels in cardiac tissue and liver of high-fat-dietfed rodents, accompanied by upregulation of CPT1, a rate-limiting enzyme for mitochondrial -oxidation (114)