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Both BuShenHuaZhuo formula and YulinTongBu formula can reduce the levels of lipopolysaccharide (LPS) and inflammatory cytokines such as TNF-, IL-6 and IL-8 in the serum of PCOS rats, and inhibit the inflammatory response mediated by the nuclear factor-B (NF-B) signaling pathway (79), but also enhance the expression of tight junction proteins (occludin and claudin1) and inhibit the expression of key genes and proteins in the TLR4/NF-B signaling pathway (85)

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For example, the pro-autophagy protein, p62, is also a downstream target the of survival and inflammatory pathway, NF-kB (115, 116)

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Expected duration of vitamin B12 deficiency With proper treatment, symptoms of vitamin B 12 deficiency begin to improve within a few days