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Most additives in nasal products primarily function as tonicity builders or emollients, with a secondary role in altering taste due to their favorable flavors

Conversely, APOE variants may also shape microbiome diversity and function, creating a bidirectional relationship

Abbreviations BBB: Bloodbrain barrier CNS: Central nervous system FMO: Frontier molecular orbital GPx4: Glutathione peroxidase 4 MD: Molecular dynamic MM/GBSA: Molecular mechanics with generalized Born and surface area solvation MolSA: Molecular surface area MS: Multiple sclerosis PSA: Polar surface area QSAR: Quantitative structureactivity relationship rGyr: Radius of gyration RMS: Root mean squared RMSD: Root mean square deviation RMSF: Root mean square fluctuation SASA: Solvent accessible surface area References B.K.T

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Comparison of the functional properties of trimeric and monomeric CaiT of Escherichia coli

62 , 63 The correlation between the different biochemical variants, the site of genetic mutation, and the extent of hemolysis is a matter of current investigation