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Further studies are needed to determine if regulated expression of p21, CASP-2, CASP-9, SOD-1 and HO-1, components of the anti-oxidant glutathione metabolic pathway GP-1 and GR-1, and the DNA damage marker GADD45 are necessary to complete differentiation in specialised keratinocyte layers

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(2) autophagy, showing cytoplasmic vacuolization and eventual lysosomal degradation after phagocytic uptake

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