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Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model

XiongXKuangHAnsariSLiuTGongJWangSet alLandscape of intercellular crosstalk in healthy and NASH liver revealed by single-cell secretome gene analysis

These advancements collectively achieve breakthroughs in smart responsiveness, biocompatibility, and therapeutic efficacy, positioning glycopeptide hydrogels as a transformative platform for advanced biomedical applications

Normally, the endothelial tight junctions are disrupted and the transmigration of leukocytes is facilitated

Hypoxemia intensifies these alterations by inducing a deficiency in the oxygen-dependent neuronal metabolism and production of neurotransmitters, resulting in accelerated brain atrophy in these patients [13]

However, under conditions of heightened oxidative stress, NO can react with superoxide to form peroxynitrite, thereby exacerbating oxidative damage