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Of the pathological mechanisms presented above, whether TMAO directly interacts with specific receptors or indirectly alters the signal pathway by changing the protein conformation remains unclear

The statistical significance was calculated using a one-sided Fishers exact test, evaluating the over-representation of functional gene sets against the null hypothesis of no association, with multiple comparison correction applied using the Benjamini-Hochberg method

Similarity and dissimilarity of thiols as anti-nitrosative agents in the nitric oxide-superoxide system

Sci (New York NY) (2017) 358(6365):9416

ND, Neurological disorder

Mol Nutr Food Res 60: 10901098, 2016 [DOI] [PMC free article] [PubMed] [Google Scholar] 27.Jain SK, Micinski D, Huning L, Kahlon G, Bass PF, and Levine SN