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Regarding the preclinical studies, this review revealed several shortcomings

Luteolin exerts its anti-fibrotic effects by suppressing AKT1 phosphorylation, thereby downregulating the PI3K/AKT signaling cascade

Until such data is available, these approaches remain theoretical and should be navigated with caution, always under strict medical supervision to ensure patient safety and treatment efficacy

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To simplify clearance of the bile duct with laparoscopic techniques and decrease the barriers to the incorporation of LC with IOC LCBDE in the pediatric population, we have developed a Seldinger-based technique for LCBDE that uses easy-to-source disposable pieces of equipment and culminates with an over-the-wire balloon dilation of the Sphincter of Oddi with antegrade flushing of stones

It is light, refreshing, and flavorful, with a hint of fruit and the right balance of tart and sweet