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Caution: plasma BDNF is poorly correlated with central BDNF

Fan S, Ma YX, Wang JA, Yuan RQ, Meng Q, Cao Y, et al

Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 24 mg for weight management: a randomised, controlled, phase 1b trial. Lancet 397(10286):17361748

A brand-new systematic review just hit the journals, and its the most comprehensive look weve seen yet at the mechanism, the MSK outcomes, and the massive safety gray areas surrounding this compound