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It is a cofactor for lysyl oxidase, the enzyme that crosslinks new collagen and elastin into mature, stable matrix proteins

Conversely, the production of itaconate in certain macrophage subsets can exert paracrine protective effects on cardiomyocytes by activating the Nrf2 antioxidant pathway (79)

In the process of assimilatory sulfate reduction, sulfate serves as a substrate for the production of amino acids

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The horrendous slaughter of nearly the entire surrendered garrison, ordered by and personally committed by British officers, occurred after Ledyard offered his sword