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These cells exhibit a distinct morphology, characterized by their large size and vacuolated appearance

The mechanism by which bacteria traverse the mucosal barrier remains unclear, with the most convincing studies suggesting that a specific transcytotic process involving specialized cells overlying the domes of intestinal lymphoid aggregates (Peyers patches) termed M-cells, which are characterized by a sparse glycocalyx, short and irregular microvilli and a microfold appearance [16, 17]

Several studies give us some solid answers

10.1038/nature19851PMID: 27509858

These mice present early changes in DA transmission and age-dependent loss of nigrostriatal DA neurons and motor impairment [58]

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