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Superoxide produced by NOX2 is converted to hydrogen peroxide by superoxide dismutase (Winterbourn et al

Qiu C-W, Chen B, Zhu H-F et al (2024) Gastrodin alleviates cisplatin nephrotoxicity by inhibiting ferroptosis via the SIRT1/FOXO3A/GPX4 signaling pathway

These pathways are dysregulated in the setting of SARS-CoV-2 to antagonize host antiviral responses and are vital for viral replication, entry, propagation, and/or apoptosis/viral release

doi: 10.1016/j.jpba.2024.116265 36 LiaoJ.GheissariR.ThomasD

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The peptide shows potential for reducing central sensitization, a key driver of chronic pain