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When the gut lining is exposed to severe irritantssuch as bacterial endotoxins (LPS) or excessive ammonia produced by dysbiotic bacteriathe epithelial cells release zonulin, which signals the tight junctions to open, increasing intestinal permeability

155 It is characterized by abnormal extracellular amyloid-beta (A) aggregates, which form diffuse and neuritic plaques, as well as hyperphosphorylated tau aggregates, which form intraneuronal neurofibrillary tangles

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Protein concentrations in lysates were determined by Protein Assay Dye Reagent (BioRad #5000006), diluted in 2x Laemmli sample buffer (BioRad Cat#1610737) with fresh -mercaptoethanol (BioRad #1610710), and heated at 95C for 5 minutes

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pylori may contribute to the development of cholangiocarcinoma caused by O