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This decline is associated with reduced energy, mental fatigue, slower cellular repair, and decreased resilience to stress

Interestingly, we observed glutamine level in ATC cell lines was higher than non-ATC groups [28], indicating that glutamine may be an important factor for ATC cell metabolism (Fig

[] Severe prolonged oxidative damage can lower glutathione levels by increased production and collection of glutathione disulphide, outflow and plasma breakdown, peptide S-glutathionylation and the formation of glutathione compounds

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Notably, redox signaling events are significant regulators of cell death pathways, among which GSH depletion has been demonstrated to be a vital early hallmark in the progression of different cell death mechanisms [18]

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