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-heguelin is a monodesmotic triterpenoid saponin isolated from Hedera nepalensis K.Koch [236], which induces apoptosis at high doses, disrupts the redox system by significantly affecting glutathione metabolism at safe and low toxic doses to induce ferroptosis in NSCLC, and also increases the sensitivity of NSCLC cells to cisplatin [237]

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J Diabetes Complicat 29:923927 Mir O, Alexandre J, Tran A, Durand JP, Pons G, Treluyer JM, Goldwasser F (2009) Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity

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